Clear cell carcinoma of the vagina










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Preconception counseling should include a discussion of increased risks of infertility, ectopic pregnancy, miscarriage, premature labor and premature birth. The relative risk of miscarriage is 1. Thus, it is possible that health effects may be found that affect elderly DES Daughters that are not currently recognized. No human studies have documented consistent findings linking DES exposure in utero to any psychological or psychiatric condition, or to sexual dysfunction.

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Health Risks And Related Concerns For Des Daughters

Although much is known about health risks among DES Daughters, many questions remain about health problems that might emerge as the cohort ages. Cytological smears of the vagina and cervix should be taken. although cases of CCA have been diagnosed in the presence of negative cytological smears. Data from a cohort of offspring of women randomized to DES or placebo during pregnancy exist, but sample sizes are relatively small. DES Daughters are at an increased risk for..

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Clinical characteristics of non

Clear cell adenocarcinoma CCA , a rare kind of vaginal and cervical cancer Increased risk for clear cell cancer appears to be highest for DES Daughters in their teens and early 20s. DES Daughters under 40 years of age did not experience an increased risk of breast cancer. However, a higher than average risk of abnormal pregnancy has been consistently documented. Concerns about an increased risk of breast cancer have also been raised for DES Daughters. Although the presence of vaginal adenosis Figure 8 , suggests DES exposure, no specific treatment is necessary 46,58, However, cases associated with in utero exposure to DES have been reported in women in their 30s and 40s Some animal studies have suggested links between prenatal exposure to androgens or estrogens and cognitive abilities differentiated by sex.

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Description: DES Daughters who present for infertility evaluation should undergo a hysterosalpingogram to assess for upper genital tract abnormalities. Studies in humans have yielded conflicting results. Some studies have suggested an increased relative risk of about 2. Any grossly visible or palpable abnormal vaginal or cervical lesion should be biopsied, regardless of cytology results. No human studies have documented consistent findings linking DES exposure in utero to any psychological or psychiatric condition, or to sexual dysfunction. The relative risk of ectopic pregnancy is 3. In the past, because of the increased risk of miscarriage in this population, prophylactic cervical cerclage was advocated for pregnant women who had been exposed to DES in utero.
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